anti-CALD1 (human), Rabbit Monoclonal (RM396)

RevMAb Biosciences

anti-CALD1 (human), Rabbit Monoclonal (RM396)

10

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM396

CALD1

caldesmon 1

caldesmon; CDM; HCAD; H-CAD; LCAD; L-CAD; NAG22; testis secretory sperm-binding protein Li 227n

Rabbit

IgG

Caldesmon

CALD1 (Caldesmon) is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This calmodulin- and actin-binding protein plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin and phospholipids. It is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation. - Recombinant Antibody. This antibody reacts to human CALD1 . Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CALD1 (Caldesmon) is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This calmodulin- and actin-binding protein plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin and phospholipids. It is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

-20°C

12352203