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Anti-CCL2 [MC32 affinity matured]

Ab03459-23.0
Absolute Antibody
ApplicationsELISA, Neutralisation/Blocking
Product group Antibodies
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-CCL2 [MC32 affinity matured]
  • Delivery Days Customer
    7
  • Application Supplier Note
    This antibody is the affinity matured version of original scFv antibody MC32. The binding characterization of this antibody to human CCL2 was done using ELISA. This antibody binds human CCL2 with a binding affinity of Kd= 1.4 nM. This antibody exhibited blocking activity for the MCP-1-induced chemotaxis of a human acute monocytic leukemia cell line, THP-1, in vitro. In the chemotaxis assay, the original parent antibody MC32 IgG inhibited the MCP-1-induced THP-1-migration 2.5-fold more strongly than MC32 scFv in reference to IC50 (PMID: 18216066).
  • Applications
    ELISA, Neutralisation/Blocking
  • Applications Supplier
    ELISA; block
  • Certification
    Research Use Only
  • Protein IDP13500
  • Protein Name
    C-C motif chemokine 2
  • Scientific Description
    This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

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The chemotactic effect of GTX00415-pro Human MCP1 / CCL2 protein (active). Upper: (A) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 without MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. (B) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 with 25 ng/ml MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. (C) THP-1 cells were seeded into the upper chambers and serum free RPMI-1640 with 50 ng/ml MCP-1 was added in lower chamber, then cells in lower chamber were observed at low magnification (x100) after incubation for 3hrs. Lower: The number of migrated cells were counted at high magnification (x400) randomly (five fields for each filter).
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