Anti-CD104 [58XB4]

Absolute Antibody

Anti-CD104 [58XB4]

9

This antibody is specific for human CD104. Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.

To investigate the recruitment of plectin into hemidesmosomes by the alpha6beta4 integrin, immunohistochemistry was performed on human MD-EBS keratinocytes using the mouse version of this antibody (Geerts et al, 1999; pmid:10525545). While showing that a subpopulation of cells in a hiPSC-derived corneal epithelial cell sheet is positive for ABCB5, flow cytometry was performed on human hiPSC-derived SEAMs using the mouse version of this antibody (Watanabe et al, 2021; pmid:34195566). The mouse version of this antibody was used in flow cytometry on differentiated human iPS cells to demonstrate the generation of a self-formed ectodermal autonomous multi-zone (SEAM) of ocular cells using human induced pluripotent stem cells (Hayashi et al, 2016; pmid:26958835). To study the intracellular accumulation of S. aureus in the epidermis of DFUs, flow cytometry was performed on single-cell suspensions from full-thickness DFU tissue from type 2 diabetes patients and control skin using the mouse version of this antibody (Pastar et al, 2021; pmid:34730110).

Flow Cytometry, ImmunoHistoChemistry

Research Use Only

Monoclonal

58XB4

ITGB4

integrin subunit beta 4

CD104; CD104 antigen; GP150; integrin beta-4

Mouse

IgG2a

Integrin beta-4

Human

-20°C,2°C to 8°C

12352203