Anti-CD11c [N418]

Absolute Antibody

Anti-CD11c [N418]

7

The antibody binds to mouse and human CD11c.

This antibody binds to human CD11, which is part of the human integrin receptor for fibrinogen, recognizing a GPR motif. The receptor is involved in cell-cell contacts, chemotaxis, and inflammatory responses. The binding of this antibody to its target was originally evaluated via FACS (Metlay et al., 1990; PMID: 2185332). This antibody was used for FC (Liu et al., 1998; PMID: 9723687). This antibody was used in vivo as a tool to target the delivery of a model antigen specifically to dendritic cells in mice, resulting in rapid and high antibody response (Wang et al., 2000; PMID: 10639168). Conjugating this antibody to synthetic peptides enhanced their immunogenicity (Berry et al., 2003; PMID: 10639168). This antibody was successfully used in an IF assay (AbAb internal results).

Flow Cytometry, ImmunoFluorescence, Other Application

ELISA

Research Use Only

Monoclonal

N418

ITGAX

integrin subunit alpha X

CD11 antigen-like family member C; CD11C; complement component 3 receptor 4 subunit; integrin alpha X; integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain; SLEB6

Mouse

IgG1

Integrin alpha-X

This chimeric mouse antibody was made using the variable domain sequences of the original Hamster IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

Mouse, Human

Hamster spleen cells that had been primed to mouse spleen dendritic cells

-20°C,2°C to 8°C

12352203