Anti-CD19 [1D3]

Absolute Antibody

Anti-CD19 [1D3]

9

The antibody is specific for mouse CD19.

The scFv fragment of the antibody was employed in the generation of a chimeric antigen receptor (CAR) which bound to CD19. Mice were administered mouse CAR-expressing cells or control cells. Anti-muCD19 CAR-T mice exhibited elevated serum IL-6 levels on day 2 after CAR-T administration, with a decrease at day 5, compared to control mice that exhibited very low or no increase in serum IL-6 levels. A20 tumor bearing mice were administered CPA and anti -mouse CD 19 CAR-T cells and evaluated for various parameters. Animals treated with CPA and anti-mouse CD 19 CAR-T cells were observed to have elevated levels of serum cytokines, as compared to controls (EP3644721A1).

Flow Cytometry

Research Use Only

Monoclonal

1D3

Cd19

CD19 antigen

AW495831; B-lymphocyte antigen CD19; differentiation antigen CD19

Rabbit

IgG

B-lymphocyte antigen CD19

Mouse

-20°C,2°C to 8°C

12352203