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anti-CD204 / MSR1 antibody [2F8]

Research Use Only
ARG22421
Arigo Biolaboratories
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityMouse
TargetMsr1
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-CD204 / MSR1 antibody [2F8]
  • Delivery Days Customer
    23
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2F8
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID20288
  • Target name
    Msr1
  • Target description
    macrophage scavenger receptor 1
  • Target synonyms
    macrophage acetylated LDL receptor I and II; macrophage scavenger receptor types I and II; MR; MRS-A; MS; MSR; MSR-A; S; Sc; Scara1; scavenger receptor type A; Scvr; SR-A; SR-AI; SR-AII
  • Host
    Rat
  • Isotype
    IgG2b
  • Scientific Description
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203