anti-CD204 / MSR1 antibody [2F8]

Arigo Biolaboratories

anti-CD204 / MSR1 antibody [2F8]

23

Flow Cytometry, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

2F8

1 mg/ml

Unconjugated

Msr1

macrophage scavenger receptor 1

MRS-A, MSR, MSR-A, SR-A, SR-AI, SR-AII, Scara1, Scvr, macrophage scavenger receptor types I and II, macrophage acetylated LDL receptor I and II, scavenger receptor type A

Rat

IgG2b

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Mouse

-20°C

12352203