Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-CD21 rabbit monoclonal antibody (Clone RM372) at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-CD21 rabbit monoclonal antibody (Clone RM372) at a 1:1000 dilution.
anti-CD21 (human), Rabbit Monoclonal (RM372)
REV-31-1258-00
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCR2
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-CD21 (human), Rabbit Monoclonal (RM372)
- Delivery Days Customer5
- Antibody SpecificityThis antibody reacts to human CD21 (Complement receptor type 2).
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM372
- FormulationLiquid
- Gene ID1380
- Target nameCR2
- Target descriptioncomplement C3d receptor 2
- Target synonymsC3DR; CD21; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor type 2; CR; CVID7; EBV receptor; SLEB9
- HostRabbit
- IsotypeIgG
- Protein IDP20023
- Protein NameComplement receptor type 2
- Scientific DescriptionCD21 (Complement Receptor 2; CR2; EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). - Recombinant Antibody. This antibody reacts to human CD21 (Complement receptor type 2). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. CD21 (Complement Receptor 2; CR2; EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9).
- ReactivityHuman
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203