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anti-CD28 (human), mAb (ANC28.1/5D10) (F(ab)2)

Research Use Only
ANC-177-520
Ancell Corporation
ApplicationsFunctional Assay, Flow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
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Overview

  • Supplier
    Ancell Corporation
  • Product Name
    anti-CD28 (human), mAb (ANC28.1/5D10) (F(ab)2)
  • Delivery Days Customer
    10
  • Applications
    Functional Assay, Flow Cytometry, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ANC28.1/5D10
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. The ligands for CD28 identified as CD80 (B7-1) and CD86 (B7-2) are immunglobulin superfamily monomeric transmembrane glycoproteins of 60kDa and 80kDa respectively. Anti-CD28 antibodies have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement. - Monoclonal Antibody. Isotype: Mouse IgG1kappa. Clone: ANC28.1/5D10. Applications: ELISA, FACS, FUNC. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl Human CD28 is an important costimulatory molecule found on all CD4+ T cells and on about half of the CD8+ T cells. T cell activities attributed to CD28 include prevention of anergy, induction of cytokine gene transcription, stabilization of cytokine mRNA and activation of CD8+ cytotoxic T lymphocytes. The ligands for CD28 identified as CD80 (B7-1) and CD86 (B7-2) are immunglobulin superfamily monomeric transmembrane glycoproteins of 60kDa and 80kDa respectively. Anti-CD28 antibodies have been shown to have a strong adjuvant effect when conjugated to an immunogen. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203