anti-CD284 / TLR4 antibody

Arigo Biolaboratories

anti-CD284 / TLR4 antibody

23

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TLR4

toll like receptor 4

ARMD10, CD284, TLR-4, TOLL, toll-like receptor 4, hToll, homolog of Drosophila toll, toll like receptor 4 protein

Rabbit

The Toll-like receptor (TLR) family in mammal comprises a family of trans-membrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and 1L-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylo-genetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Amount this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediatiors of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 839 amino acids, with an approximate molecular weight of 90kDa (6).1. JMuzio M., Natoli G. , Saccan S., Levrero M., and Mantovani A. (1998) J. Exp. Med. 187: 2097-2101.2. Medzhitov R. and Janeway C.A (1997). Cell 91: 295-298.3. Chuang T.H. and Ulevitch R.J. (2001) Biochim. Biophys. Acta 1518 (1-2): 157-161).4. Takeuchi O., et al. (1999) Immunity 11: 443.5. Poltorak A., Riccardi-Castagnoli P., Citterio S., and Butler B. (2000) Proc. Natl. Acad. Sci USA 97: 2163-2167.6. Medzhitov R., Preston-Hurlburt P. and Janeway C.A. (1997) Jr. Nature 388 (6640): 394-397.

Human

-20°C

12352203