Anti-CD3 [CD3B219]

Absolute Antibody

Anti-CD3 [CD3B219]

7

The antibody is specific for CD3 epsilon.

The antibody was used to construct different CD33 xCD3 bispecific antibodies (IgG4). In vitro T cell mediated cytotoxicity assays were performed using the bispecific antibody and the cytotoxicity was measured by flow cytometry. Ex vivo cytotoxicity assay showed the paired antibody promoted a dose-dependent reduction of total cytotoxicity that correlated with T cell activation after 48 hours (US20210040209A1). The antibody is considered a high affinity binder (Kd= 8mM) (US20210214440A1). The CD33xCD3 bispecific antibodies specifically induce cell cytotoxicity of MOLM-13 cells and CD33+ monocytes at 48 hr (US20200048349A1).

Flow Cytometry, Other Application

FC; in vitro

Research Use Only

Monoclonal

CD3B219

CD3E

CD3e molecule

CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE

Human

IgG4

T-cell surface glycoprotein CD3 epsilon chain

Human, Monkey

Human, monkey

-20°C,2°C to 8°C

12352203