Anti-CD33 [hP67.6 (Gemtuzumab)]

Absolute Antibody

Anti-CD33 [hP67.6 (Gemtuzumab)]

7

Recognises human CD33.

A human IgG4 variant conjugated to derivative of the cytotoxic drug calicheamicin gamma 1, N-acetylcalicheamicin dimethyl hydrazide, has been used as a therapeutic against acute myeloid leukemia. This antibody may also be used in flow cytometry and immunofluorescence.

Flow Cytometry, ImmunoFluorescence

FC; IF

Research Use Only

Monoclonal

hP67.6 (Gemtuzumab)

CD33

CD33 molecule

CD33 antigen (gp67); CD33 molecule transcript; gp67; myeloid cell surface antigen CD33; p67; sialic acid-binding Ig-like lectin 3; SIGLEC3; SIGLEC-3

Mouse

IgG1

Myeloid cell surface antigen CD33

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed on predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells.

-20°C,2°C to 8°C

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