anti-CD4 (human), Rabbit Monoclonal (RM345)

RevMAb Biosciences

anti-CD4 (human), Rabbit Monoclonal (RM345)

5

This antibody reacts to the extracellular domain of human CD4.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM345

Liquid

CD4

CD4 molecule

CD4 antigen (p55); CD4 receptor; CD4mut; IMD79; OKT4D; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Rabbit

IgG

T-cell surface glycoprotein CD4

Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T helper cells and on some monocyte macrophage lineage cells and dendritic cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen and also in specific regions of the brain, gut and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T cell activation through its association with the T cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. - Recombinant Antibody. This antibody reacts to the extracellular domain of human CD4. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Human CD4 is a cell surface glycoprotein of 55kDa expressed on most thymocytes, on about two thirds of peripheral T helper cells and on some monocyte macrophage lineage cells and dendritic cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The N-terminal region of CD4 is a receptor for the HIV-1 viral protein gp120. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen and also in specific regions of the brain, gut and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T cell activation through its association with the T cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system.

Human

-20°C,2°C to 8°C

12352203