Anti-CD4 [MT310]

Absolute Antibody

Anti-CD4 [MT310]

7

This antibody strongly inhibits HIV-1 gp120-binding to CD4, which blocks HIV infectivity of CD4+ T lymphocytes, as well as the binding of MHCII, which results in the block of T-cell activation (possibly leading to anergy induction) (Qin et al., 2001; PMID: n/a). Additionally, antibody binding to CD4 leads to GM-CSF, TNF-alpha and IL-10 induction. (TNF-alpha induction only occurs after 20 hours.)

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

WB; IP; IF; IHC-P; FC

Research Use Only

Monoclonal

MT310

CD4

CD4 molecule

CD4mut, IMD79, Leu-3, OKT4D, T4, T-cell surface glycoprotein CD4, CD4 antigen (p55), CD4 receptor, T-cell surface antigen T4/Leu-3

Mouse

IgG1

T-cell surface glycoprotein CD4

Human, Monkey, Primate

Human, Rhesus Monkey, Cynomolgus Monkey

-20°C,2°C to 8°C

41116161