Anti-CD40 [A54 scFv]

Absolute Antibody

Anti-CD40 [A54 scFv]

9

A54 binds specifically to the D1 domain of CD40 (and can only bind to the intact, i.e., non-truncated version of CD40, and when an AD2 peptide tag has not been added) and can recognise CD40 on a B cell line (BJAB). The scFv version of this antibody binds

A54 is able to block the CD40-CD154 interaction by around 60-80% and can also induce CD40 sinalling in human B cells when at unusually high concentrations (The CD40 receptor - target, tool and technology, Ellmark, 2002). This scFv can also be used for ELISA studies (PMID: 12153507)

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

A54 scFv

CD40

CD40 molecule

B cell surface antigen CD40; B cell-associated molecule; Bp50; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5

Mouse

IgG2a

Tumor necrosis factor receptor superfamily member 5

This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203