Anti-CD44 [NKI-P1]

Absolute Antibody

Anti-CD44 [NKI-P1]

7

This antibody is specific for human CD44. CD44 is a cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment.

To determine the expression of CD44 in oral squamous cell carcinoma associated endothelial cells, immunohistochemistry was used on squamous cell carcinoma tissues using the mouse version of this antibody (Essa and Deraz, 2021). To explore the role of CD44 splicing in the regulation of cell binding to HA, flow cytometry was used on Namalwa and COS transfectants using the mouse version of this antibody (van der Voort, 2000). To study expression of CD44 in human colorectal cancer, immunohistochemistry was performed on normal and pathological tissue using the mouse version of this antibody (Wielenga et al, 1993; pmid:7691404). Immunohistochemistry was performed on normal and colorectal neoplasia tissue using the mouse version of this antibody to study expression of CD44 in normal tissue and colorectal neoplasia tissue (Heider et al, 1993; pmid:8416989). To study the expression of CD44 in primary brain tumours, flow cytometry was performed on glioma cell cultures using the mouse version of this antibody. Furthermore, primary brain tumours were stained for immunohistochemistry using this antibody (Kaaijk et al, 1995; pmid:8750184). An aggregation assay using the mouse version of this antibody was performed on JY, an EBV-transformed B cell line to demonstrate that triggering CD44 promotes cell adhesion (Koopman et al, 1990; pmid:2246503). To study the use of endothelial CD44 as a target for anticancer therapy, an immunotoxin assay was performed on HUVEC and the human CD44 expressing keratinocyte cell line HaCaT using the mouse version of this antibody (Griffioen et al, 1997; pmid:9242547).

Functional Assay, Flow Cytometry, ImmunoHistoChemistry

IHC; FC; functional assay

Research Use Only

Monoclonal

NKI-P1

CD44

CD44 molecule (Indian blood group)

CD44 antigen; CDW44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; epican; extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronate receptor; IN; Indian blood group antigen; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; phagocytic glycoprotein 1; soluble CD44

Mouse

IgG1

CD44 antigen

Human

Human

The mouse version of this antibody was raised by immunizing a BALB/c mouse with immunoprecipitated LFA-I family antigen.

-20°C,2°C to 8°C

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