Anti-CD45 Mouse mAb

PTM BIO

Anti-CD45 Mouse mAb

5

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF, FC

Research Use Only

Monoclonal

JMMR-2664B

Unconjugated

Mouse

IgG

Receptor-type tyrosine-protein phosphatase C

CD45 is a type I transmembrane protein comprised of a pair of intracellular tyrosine phosphatase domains and a variable extracellular domain generated by alternative splicing. The catalytic activity of CD45 is a function of the first phosphatase domain (D1) while the second phosphatase domain (D2) may interact with and stabilize the first domain, or recruit/bind substrates. CD45 interacts directly with antigen receptor complex proteins or activates Src family kinases involved in the regulation of T- and B-cell antigen receptor signaling. Specifically, CD45 dePhosphorylatedrylates Src-family kinases Lck and Fyn at their conserved negative regulatory carboxy-terminal tyrosine residues and upregulates kinase activity. Conversely, studies indicate that CD45 can also inhibit Lck and Fyn by dePhosphorylatedrylating their positive regulatory autoPhosphorylatedrylation site. CD45 appears to be both a positive and a negative regulator that conducts signals depending on specific stimuli and cell type.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203