Anti-CD45RB [PD7/26]

Absolute Antibody

Anti-CD45RB [PD7/26]

7

This antibody recognises CD45RB which is a transmembrane tyrosine phosphatase that is present on all leukocytes and regulates the threshold of T cell antigen receptor signaling. There are multiple CD45R isoforms resulting from the alternative splicing of

This antibody has been widely used in the identification of leukocytes (as CD45 is a pan-leukocyte marker) and lymphatic tumours in paraffin-embedded tissue sections. For instance, one group utilised it during the morphological characterisation of patient-derived xenografts via immunohistochemical staining of formalin-fixed, paraffin-embedded samples (Chijiwa et al., 2015). Another group used this antibody for immunofluorescence staining of similarly prepared fibroblast samples in chronic obstructive pulmonary disease (Brand et al., 2015). Finally, Deckert-Schlueter and colleagues (1998) used PD7/26 antibody when researching primary CNS lymphomas.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

IHC; IF; FACS; WB

Research Use Only

Monoclonal

PD7/26

PTPRC

protein tyrosine phosphatase receptor type C

B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen

Human

IgG4

Receptor-type tyrosine-protein phosphatase C

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising Balb/c mice with cells from a human peripheral-blood lymphocyte line maintained in T-cell growth factor.

-20°C,2°C to 8°C

12352203