Anti-CD48 [OX-45]

Absolute Antibody

Anti-CD48 [OX-45]

7

OX-45 binds specifically to CD48 on rat thymocytes, T and B cells and endothelium but not LFA.3. Directly competes with CD46 for binding the target epitope. CD48 is a CD2 ligand and is expressed on the surface of all hematopoietic cells and endothelium. M

Describes the use of OX-45 in blocking the primary mixed lymphocyte response (MLR)and the secondary response of T lymphocytes to the soluble antigen DNP-BGG. It also showed that OX-45 did not have any effect on the cytotoxic activity of specific (CTL) or non-specific (NK) killer cells or on proliferative responses stimulated by lectins or oxidative mitogenesis.

Flow Cytometry, Neutralisation/Blocking

blocking; FC

Research Use Only

Monoclonal

OX-45

Cd48

Cd48 molecule

BCM1 surface antigen; BLAST-1; CD48 antigen; MRC OX-45 surface antigen; signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF2

Rat

IgG2b

CD48 antigen

This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Rat

Rat

OX-45 was prepared by immunizing BALB/c mice with rat T blasts prepared by stimulating purified T helper (TH) cells with allogeneic irradiated rat spleen cells.

-20°C,2°C to 8°C

12352203