Anti-CD7 [3A1f]

Absolute Antibody

Anti-CD7 [3A1f]

9

The binding affinity of the scFv version of this antibody was determined using surface plasmon resonance. The affinity of the scFv antibody for human CD7 was found to be 1.8 nM. This the scFv version of this antibody was also used in the generation of single-chain Fv (scFv) immunotoxins specific for the T cell-associated antigen CD7 as a novel therapeutic agent for treatment of human T cell malignancies (PMID: 9120282). This antibody was also used in the generation of a therapeutic fusion protein scFvCD7:sTRAIL, designed to induce target antigen-restricted apoptosis in human T-cell tumors. The binding of the fusion protein to CD7 was tested with flow cytometry (PMID: 15833872).

Flow Cytometry

Research Use Only

Monoclonal

3A1f

CD7

CD7 molecule

GP40, LEU-9, TP41, Tp40, T-cell antigen CD7, CD7 antigen (p41), T-cell leukemia antigen, T-cell surface antigen Leu-9, p41 protein

Human

IgG1

T-cell antigen CD7

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203