Anti-CD70 [BU69]

Absolute Antibody

Anti-CD70 [BU69]

9

This antibody binds human CD70, which is the CD27 ligand. This protein is present only on activated dendritic cells and T lymphocytes, and represents a therapeutic target of relevance for autoimmune diseases.

BU69 has been used for FACS and immunocytochemistry analysis of the cell-surface expression levels of CD70 in renal cell carcinomas (Adam et al, 2006). It was shown in this study that cell-surface binding of BU69 to CD70 caused rapid internalisation of the cell-surface glycoprotein.

Flow Cytometry, ImmunoPrecipitation, ImmunoHistoChemistry

Research Use Only

Monoclonal

BU69

CD70

CD70 molecule

CD27 ligand; CD27L; CD27-L; CD27LG; CD70 antigen; Ki-24 antigen; LPFS3; surface antigen CD70; TNFSF7; TNLG8A; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7

Human

IgG4

CD70 antigen

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203