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anti-CrkII antibody

Research Use Only
ARG54108
Arigo Biolaboratories
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
TargetCRK
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-CrkII antibody
  • Delivery Days Customer
    23
  • Applications
    Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1398
  • Target name
    CRK
  • Target description
    CRK proto-oncogene, adaptor protein
  • Target synonyms
    adapter molecule crk; CRKII; p38; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein
  • Host
    Mouse
  • Isotype
    IgG2b
  • Scientific Description
    The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203