Anti-CXCR3 [V44D7]

Absolute Antibody

Anti-CXCR3 [V44D7]

7

The binding characterization of this antibody to human CXCR3 was done using competitive ELISA. This antibody is capable of inhibiting binding of 125I-labeled IP-10 and -I-Tac to primary Th1 cells. This antibody can be used for the study of expression of CXCR3 on the surface of Th1 cells using flow cytometry. This antibody also inhibited Th1 cell migration mediated by CXCR3 chemokines (US8435522).

Flow Cytometry, ELISA, Neutralisation/Blocking

ELISA; FC; inhibit

Research Use Only

Monoclonal

V44D7

CXCR3

C-X-C motif chemokine receptor 3

CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C chemokine receptor type 3, G protein-coupled receptor 9, IP-10 receptor, Mig receptor, chemokine (C-X-C motif) receptor 3, chemokine receptor 3, interferon-inducible protein 10 receptor

Human

IgG1

C-X-C chemokine receptor type 3

Human

Human

The original antibody was generated by immunizing BALB/c mice with CXCR-3 expressing NSO cells. The humanized version of the antibody was created by grafting CDRs of the original murine antibody onto human framework regions.

-20°C,2°C to 8°C

41116161