Anti-CXCR3 [V44D7]

Absolute Antibody

Anti-CXCR3 [V44D7]

9

This antibody binds human CXCR3. This protein acts as a receptor for C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling path

The binding characterization of this antibody to human CXCR3 was done using competitive ELISA. This antibody is capable of inhibiting binding of 125I-labeled IP-10 and -I-Tac to primary Th1 cells. This antibody can be used for the study of expression of CXCR3 on the surface of Th1 cells using flow cytometry. This antibody also inhibited Th1 cell migration mediated by CXCR3 chemokines (US8435522).

Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

V44D7

CXCR3

C-X-C motif chemokine receptor 3

CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; CMKAR3; C-X-C chemokine receptor type 3; G protein-coupled receptor 9; GPR9; interferon-inducible protein 10 receptor; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R

Mouse

IgG2b

C-X-C chemokine receptor type 3

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203