Anti-CXCR4 [14D09], Camelid VHH, His-tagged,

Absolute Antibody

Anti-CXCR4 [14D09], Camelid VHH, His-tagged,

9

The binding of the original version of this antibody (VHH) to CXCR4-expressing viral lipoparticles was characterized in an ELISA. Furthermore, it was analyzed for its ability to compete with the ligand CXCL12 (or SDF-1a) for receptor binding by displacement of biotinylated SDF-1 on Caki-CXCR4 cells in flow cytometry. This antibody exhibited medium affinity to its target (EC50/kD of 1 < x ≤ 10 nM) and a ligand inhibition (IC50 1 < x < 10 nM). In its bi-specific construction with clone 57A07, it served a functional role (US20220242958).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

14D09

CXCR4

C-X-C motif chemokine receptor 4

CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, WHIMS1, C-X-C chemokine receptor type 4, CD184 antigen, LPS-associated protein 3, SDF-1 receptor, chemokine (C-X-C motif) receptor 4, fusin, leukocyte-derived seven transmembrane domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor

Camel

C-X-C chemokine receptor type 4

Human

-20°C,2°C to 8°C

12352203