Anti-CXCR4 [I-3859 ]

Absolute Antibody

Anti-CXCR4 [I-3859 ]

7

The binding of this antibody to human CXCR4 was tested using ELISA. This antibody is capable of immunoprecipitating both CXCR4 monomers and dimers. I-3859 can also recognize CXCR4 present on NIH3T3-hCXCR4 transfected cells, MDA-MB-231,U937 promyelocytic cancer cells and Hela cervix cancer cells by flow cytometry. This antibody is also found to compete with other Anti-CXCR4 mAb 515H7 for binding to cell membrance as analyzed by flow cytometry. This antibody can be used for the immunohistochemical staining of tumor cells expressing CXCR4. It was used for the staining of RAMOS and KARPAS299 xenograft tumor cells (US20140170677).

Flow Cytometry, ImmunoPrecipitation, ELISA, ImmunoHistoChemistry

ELISA; IP; FC; IHC

Research Use Only

Monoclonal

I-3859

CXCR4

C-X-C motif chemokine receptor 4

CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; C-X-C chemokine receptor type 4; D2S201E; FB22; fusin; HM89; HSY3RR; LAP3; LAP-3; LCR1; LESTR; leukocyte-derived seven transmembrane domain receptor; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; SDF-1 receptor; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM; WHIMS; WHIMS1

Mouse

IgG1

C-X-C chemokine receptor type 4

Human

The original antibody was generated by immunizing BALB/c mice with recombinant NIH3T3-CXCR4 cells and/or peptides corresponding to CXCR4 extracellular N-term and loops.

-20°C,2°C to 8°C

12352203