anti-DDIT3 (human), Rabbit Monoclonal (RM485)

RevMAb Biosciences

anti-DDIT3 (human), Rabbit Monoclonal (RM485)

10

Western Blot

Research Use Only

Monoclonal

RM485

DDIT3

DNA damage inducible transcript 3

AltDDIT3; alternative DDIT3 protein; C/EBP zeta; c/EBP-homologous protein 10; C/EBPzeta; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP10; CHOP-10; DNA damage-inducible transcript 3 protein; GADD153; growth arrest and DNA damage-inducible protein GADD153

Rabbit

IgG

DNA damage-inducible transcript 3 protein

DDIT3 [GADD153] is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP DDIT3 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of DDIT3 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane. DDIT3 is a multifunctional transcription factor in endoplasmic reticulum (ER) stress response that plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. - Recombinant Antibody. This antibody reacts to human DDIT3 (DNA damage-inducible transcript 3 protein). Source: Rabbit. Isotype: Rabbit IgG. Immunogen: A peptide corresponding to the N-terminus of human DDIT3 (DNA damage-inducible transcript 3 protein). Applications: WB. DDIT3 [GADD153] is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP DDIT3 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of DDIT3 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane. DDIT3 is a multifunctional transcription factor in endoplasmic reticulum (ER) stress response that plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress.

-20°C

12352203