anti-Desmoplakin I+II antibody [DP-2.15]

Arigo Biolaboratories

anti-Desmoplakin I+II antibody [DP-2.15]

23

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

DP-2.15

1 mg/ml

Unconjugated

DSP

desmoplakin

250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; desmoplakin; DP

Mouse

IgG1

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203