Anti-Do (b) [Mima-73]

Absolute Antibody

Anti-Do (b) [Mima-73]

9

This antibody is specific for Dombrock b, a blood group antigen carried by ART4. Haemagglutination studies have shown this antibody to react with RBCs from non-human primates, including chimpanzee and orangutan (Mogos et al, 2003).

The specificity of this antibody has been confirmed in haemagglutination studies, where it reacts with Do(a-b+) and Do(a+b+) RBCs, but not with Do(a+b-) RBCs (Grodecka et al, 2012). The epitope recognised by this antibody is resistant to treatment with papain, alpha-chymotrypsin and neuraminidase, and sensitive to treatment with trypsin and DTT (Grodecka et al, 2012). This antibody has been used, as part of a panel of antibodies specific for different epitopes on the Dombrock glycoprotein, in flow cytometric and haemagglutination analysis of human red blood cells (Mayer et al, 2010; Costa et al, 2010).

Mima-73

ART4

ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

ADP-ribosyltransferase 4 (DO blood group); ADP-ribosyltransferase 4 (Dombrock blood group); ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; CD297; DO; Do glycoprotein; DO/ART4; DOK1; Dombrock blood group carrier molecule; Dombrock glycoprotein; ecto-ADP-ribosyltransferase 4; mono-ADP-ribosyltransferase 4; NAD(+)--protein-arginine ADP-ribosyltransferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; truncated Dombrock blood group protein

Ecto-ADP-ribosyltransferase 4

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2c format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203