Anti-DR4 [mAY4]

Absolute Antibody

Anti-DR4 [mAY4]

7

mAY4 was shown to bind DR4, but not other related homologs, using ELISAs and SPR (Sung et al, 2009). The mAb and scFv-reformatted version were also used in cell viability assays for assessment of tumouricidal activity. More recently, the mAY4 CDRs were humanised and expressed as an scFv-reformatted antibody fragment (Lee et al, 2010), although the humanised version had a 10-fold lower affinity for DR4.

Western Blot, ELISA, Other Application

ELISA; SPR; WB

Research Use Only

Tumor necrosis factor receptor superfamily member 10A

This full-length, chimeric human antibody was made using the variable domain sequences of the original Chicken scFv format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203