TRAIL-R1 (human):Fc (human) (rec.)

AdipoGen Life Sciences

TRAIL-R1 (human):Fc (human) (rec.)

10

Research Use Only

1 mg/ml

>95%

Tumor necrosis factor receptor superfamily member 10A

Protein. The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.01EU/microg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to human and mouse TRAIL. Purity: >95% (SDS-PAGE). TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. - TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

-20°C,2°C to 8°C

12352202