Anti-EGFR [7D12], Human IgG1-Fc Fusion,

Absolute Antibody

Anti-EGFR [7D12], Human IgG1-Fc Fusion,

9

This antibody is specific for the ligand binding site on domain III of the extracellular domain of human EGFR, overlapping with the epitope of cetuximab.

The binding of the original version of this antibody (VHH) to EGFR was characterized in an SPR (KD 0.012 nM), ELISA, (EC50 of 71.0 nM), and FACS (EC50 of 0.79 nM). In its bi-specific construction with Ab04388 (Anti-CEACAM5 [NbCEA5]), it served a functional role (US20220242958).

ELISA, Other Application

Research Use Only

Monoclonal

7D12

EGFR

epidermal growth factor receptor

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; ERRP; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1

Human

IgG1

Epidermal growth factor receptor

This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203