Anti-Estrogen receptor [S72 (scFv7)]

Absolute Antibody

Anti-Estrogen receptor [S72 (scFv7)]

9

This antibody is specific for the amino acid residues 284-310 of human estrogen receptor (hER-alpha36). The estrogen receptor is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene express

To characterize the binding of this antibody an ELISA was performed against biotinylated ERalpha36 using the scFv version. The scFv version of this antibody can also recognize human ERalpha36 in a western blot assay. And to identify the therapeutic advantages of this antibody, BCAP-37 tumors were implanted in balb/c nude mice after which the scFv version of this antibody was administered. The tumor sizes showed a significant difference with the control group (US20110311517).

Western Blot, ELISA

Research Use Only

Monoclonal

S72 (scFv7)

ESR1

estrogen receptor 1

E2 receptor alpha; ER; Era; ER-alpha; ESR; ESRA; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; ESTRR; NR3A1; nuclear receptor subfamily 3 group A member 1; oestrogen receptor alpha

Human

IgG1

Estrogen receptor

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203