Anti-Factor VIII [KM33]

Absolute Antibody

Anti-Factor VIII [KM33]

9

The scFv version of this antibody was capable of inhibiting factor VIII activity with inhibition titre of 97 BU/mg. The scFv antibody binds human factor VIII light chain with a binding affinity of Kd= 0.1 nM. It was reported that scFv KM33 inhibits the procoagulant activity of factor VIII, although its epitope is located outside region R1803-K1818 (PMID: 11159524). It was reported that the presence of this antibody completely inhibited FVIII endocytosis by both monocyte and bone marrow derived mouse dendritic cells (PMID: 21962992). It was reported that this antibody inhibits FVIII activity and interactions with its physiological ligands, von Willebrand factor, phospholipids and catabolic receptors in vitro (PMID: 11159524; Limburg V et al., 2005).

Functional Assay, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

KM33

F8

coagulation factor VIII

AHF, DXS1253E, F8B, F8C, FVIII, HEMA, THPH13, coagulation factor VIII, antihemophilic factor, coagulation factor VIII A1 domain, coagulation factor VIII C2 domain, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, factor VIII F8B

Human

IgG1

Coagulation factor VIII

Human

-20°C,2°C to 8°C

12352203