Anti-Factor VIII [KM41]

Absolute Antibody

Anti-Factor VIII [KM41]

9

The scFv version of this antibody was capable of inhibiting factor VIII activity with inhibition titre of 63 BU/mg. The scFv antibody binds human factor VIII light chain with a binding affinity of Kd= 1.6 nM (PMID: 11159524). It was reported that scFv KM33 inhibits the procoagulant activity of factor VIII. In view of the similar epitope specificity of scFv KM41 and CLB-CAg A (antibody which binds a synthetic peptide comprising residues R1803-K1818), it is likely that scFv KM41 competes with factor IXa for binding to the factor VIII light chain (PMID: 11159524).

Functional Assay, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

KM41

F8

coagulation factor VIII

AHF, DXS1253E, F8B, F8C, FVIII, HEMA, THPH13, coagulation factor VIII, antihemophilic factor, coagulation factor VIII A1 domain, coagulation factor VIII C2 domain, coagulation factor VIII, procoagulant component, coagulation factor VIIIc, factor VIII F8B

Human

IgG1

Coagulation factor VIII

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203