Anti-FAS [HFE7A], Rabbit IgG, kappa

Absolute Antibody

Anti-FAS [HFE7A], Rabbit IgG, kappa

9

This antibody is specific for human and mouse FAS.

The original antibody was used for flow cytometry on activated T cells from humans, chimpanzees, Japanese monkeys, crab-eating monkeys and marmosets, and on thymocytes from BALB/c mice. Here it was determined that this antibody was reactive to humans and mice. This antibody was used for a cytotoxic assay on synovial cells (Ichikawa et al., 2000; PMID:10744657). The structure of the original antibody was determined using x-ray crystallography (Ito et al., 2002; PMID:11754745, Haruyama et al., 2002; PMID:12499636). This antibody was used for a competitive ELISA on Fas (Haruyama et al., 2002; PMID:12499636, Yoshida et al., 2010; PMID:20024619). This antibody was used for surface plasmon resonance on mouse Fas, to determine binding affinity. The protective effects of this antibody against acute and lethal hepatic injury induced by Jo2 was assessed. It showed it was able to protect against hepatic injury. To assess the effect of this antibody on caspases in vivo, mice were injected with the antibody after Jo2-induced apoptosis of hepatocytes. It showed that it strongly inhibited activation of caspases (Yoshida et al., 2010; PMID:20024619).

Flow Cytometry, ELISA, Other Application

Research Use Only

Monoclonal

HFE7A

FAS

Fas cell surface death receptor

ALPS1A; APO-1; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6

Rabbit

IgG

Tumor necrosis factor receptor superfamily member 6

Human, Mouse

-20°C,2°C to 8°C

12352203