Fas antibody [N3C2], Internal

GeneTex

Fas antibody [N3C2], Internal

9

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.7 mg/ml

Unconjugated

FAS

Fas cell surface death receptor

ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6, tumor necrosis factor receptor superfamily member 6, APO-1 cell surface antigen, CD95 antigen, FASLG receptor, Fas (TNF receptor superfamily, member 6), Fas AMA, TNF receptor superfamily member 6, apoptosis antigen 1, apoptosis signaling receptor FAS, apoptosis-mediating surface antigen FAS, mutant tumor necrosis receptor superfamily member 6, tumor necrosis factor receptor superfamily, member 6

Rabbit

IgG

Tumor necrosis factor receptor superfamily member 6

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq]

Human

-20°C or -80°C,2°C to 8°C

12352203