Anti-GPIIb/IIIa [10E5]

Absolute Antibody

Anti-GPIIb/IIIa [10E5]

7

The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2+/-6 nM. The antibody completely inhibits platelet aggregation at 7.8 microg/ml.

The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmanns thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.

ImmunoFluorescence, Western Blot, ELISA

ELISA; WB; IF

Research Use Only

Monoclonal

10E5

ITGA2B

integrin subunit alpha 2b

alphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPalpha IIb; GPIIb; GT; GT1; GTA; HPA3; integrin alpha-IIb; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93

Rabbit

IgG

Integrin alpha-IIb

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Human blood platelets.

-20°C,2°C to 8°C

12352203