anti-HDAC3 (human), Rabbit Monoclonal (RM439)

RevMAb Biosciences

anti-HDAC3 (human), Rabbit Monoclonal (RM439)

5

This antibody reacts to human HDAC3.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

RM439

Liquid

HDAC3

histone deacetylase 3

HD3; histone deacetylase 3; KDAC3; RPD3; RPD3-2; SMAP45

Rabbit

IgG

Histone deacetylase 3

HDAC3 is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression and other developmental related functions. HDAC3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also thought to participate in transcriptional regulation through binding to YY1, a zinc-finger transcription factor. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. The HDAC3 gene is regarded as a potential tumor suppressor gene. - Recombinant Antibody. This antibody reacts to human HDAC3. Apllication: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. HDAC3 is a histone deacetylase and is responsible for the deacetylation of lysine residues on core histones and other histone substrates. The deacetylation of histones is important for transcriptional regulation, cell cycle progression and other developmental related functions. HDAC3 represses gene expression by participating in the transcriptional repressor activity of BCL6, by deacetylating H3K27 on enhancer elements. It is also thought to participate in transcriptional regulation through binding to YY1, a zinc-finger transcription factor. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. The HDAC3 gene is regarded as a potential tumor suppressor gene.

Human

-20°C,2°C to 8°C

12352203