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ProductsBack/Anti-Hu CD222 Biotin

Anti-Hu CD222 Biotin

1B-315
EXBIO
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman, Primate
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Overview

  • Supplier
    EXBIO
  • Product Name
    Anti-Hu CD222 Biotin
  • Delivery Days Customer
    7
  • Application Supplier Note
    Flow cytometry: Extracellular and intracellular staining; recommended dilution: 2-6 microg/ml. Western blotting: Recommended dilution: 1 microg/ml; non-reducing conditions.
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clone ID
    MEM-238
  • Concentration
    1 mg/ml
  • Conjugate
    Biotin
  • Isotype
    IgG1
  • Scientific Description
    CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
  • Reactivity
    Human, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

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