Anti-human Galectin 9 [1G3], Human IgG1, kappa

Absolute Antibody

Anti-human Galectin 9 [1G3], Human IgG1, kappa

9

This antibody is specific for human Gal-9 but exhibits cross-binding of murine Gal-9.

The binding and binding specificity of the original format of this antibody to c-terminus Gal-9 were assessed via ELISA. Epitope mapping was also done using ELISA. Furthermore, this antibody was successfully used in WB and IHC assays (Barjon et al., 2012; PMID: 22805533). An scFv-CAR version of this antibody with therapeutic potential was developed and described (US20230295564A1). This antibody was successfully used to neutralize LGALS9 in a study focused on pancreatic neoplastic lesions (Quilbe et al., 2023; PMID: 38098486). This antibody was used in a T lymphocyte proliferation assay, specifically in assessing the immunomodulatory properties of extracellular vesicles (C15SEVs) derived from nasopharyngeal carcinoma and recombinant Galectin-9S. In this assay, the antibody was used to block the impact of C15SEVs and recombinant Galectin-9 on peripheral blood mononuclear cells (Lefebvre et al., 2023; PMID: 38117000).

Functional Assay, Western Blot, ELISA, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

1G3

LGALS9

galectin 9

ecalectin; gal-9; galectin-9; HUAT; lectin, galactoside-binding, soluble, 9; LGALS9A; tumor antigen HOM-HD-21; urate transporter/channel protein

Human

IgG1

Galectin-9

Human, Mouse

-20°C,2°C to 8°C

12352203