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Immunohistochemical staining of formalin fixed and paraffin embedded human glioblastoma using Anti-IDH1(R132H) Rabbit Monoclonal Antibody (Clone RM390) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human glioblastoma using Anti-IDH1(R132H) Rabbit Monoclonal Antibody (Clone RM390) at a 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human glioblastoma using Anti-IDH1(R132H) Rabbit Monoclonal Antibody (Clone RM390) at a 1:100 dilution.

anti-IDH1 (R132H) (human), Rabbit Monoclonal (RM390)

REV-31-1276-00
RevMAb Biosciences
ApplicationsImmunoHistoChemistry
Product group Antibodies
TargetIDH1
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-IDH1 (R132H) (human), Rabbit Monoclonal (RM390)
  • Delivery Days Customer
    10
  • Applications
    ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM390
  • Gene ID3417
  • Target name
    IDH1
  • Target description
    isocitrate dehydrogenase (NADP(+)) 1
  • Target synonyms
    epididymis luminal protein 216; epididymis secretory protein Li 26; epididymis secretory sperm binding protein; HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase 1 (NADP+), soluble; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; oxalosuccinate decarboxylase; PICD
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO75874
  • Protein Name
    Isocitrate dehydrogenase [NADP] cytoplasmic
  • Scientific Description
    Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma. - Recombinant Antibody. This antibody reacts to human IDH1(R132H). Applications: IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203

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Figure 4. IHC analysis of IDH1 using anti-IDH1 antibody (PB9601). IDH1 was detected in paraffin-embedded section of Human Intestinal Cancer Tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1microg/ml rabbit anti-IDH1 Antibody (PB9601) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen.
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