Anti-IGF1R Antibody

HUABIO

Anti-IGF1R Antibody

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

IGF1R

insulin like growth factor 1 receptor

CD221, IGFIR, IGFR, JTK13, insulin-like growth factor 1 receptor, IGF-I receptor

Rabbit

IgG

Insulin-like growth factor 1 receptor

Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.

Human

Human

-20°C,2°C to 8°C

41116161