Anti-IGF1R [IGFR 24-31]

Absolute Antibody

Anti-IGF1R [IGFR 24-31]

9

This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically an epitope in the alpha subunit (amino acids 283-440). It does not cross-react with rat or mouse I

The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992).This antibody efficiently precipitates IGF1R solubilized from IGF1R/3T3 cells and receptor-IGF1 complexes (Soos et al, 1992). When immobilised, this antibody has been shown to remove essentially all soluble IGF1R in immunodepletion experiments (Soos et al, 1992). Additionally, this antibody has been used, as part of a panel, in the immunohistochemical staining of large cell neuroendocrine carcinoma and small cell lung carcinoma (Nitadori et al, 2006) and breast carcinoma tissue microarray samples (Hartog et al, 2011).

ImmunoPrecipitation, ImmunoHistoChemistry

Research Use Only

Monoclonal

IGFR 24-31

IGF1R

insulin like growth factor 1 receptor

CD221; IGF-I receptor; IGFIR; IGFR; insulin-like growth factor 1 receptor; JTK13; soluble IGF1R variant 1; soluble IGF1R variant 2

Mouse

IgG1

Insulin-like growth factor 1 receptor

Human

-20°C,2°C to 8°C

12352203