Anti-IL-13 [M1295]

Absolute Antibody

Anti-IL-13 [M1295]

7

This antibody can bind human IL13 in an ELISA. The affinity of original IgG1 antibody for wild type human IL-13 was determined by BIAcore to be 5.7 +/- 1.3 pM (PMID: 20226193). Preclinical studies confirm the functional effects of M1295-mediated neutralization of human IL-13 in human cell based in vitro assays using mechanistically relevant endpoints associated with the pathogenesis of asthma, atopic dermatitis, and eosinophil-mediated disease (US8399630).

ELISA, Neutralisation/Blocking

ELISA; neutralize; therapeutic

Research Use Only

Monoclonal

M1295

IL13

interleukin 13

IL-13, P600, interleukin-13

Human

IgG1

Interleukin-13

Human

Human

The original mouse antibody m836 was generated by immunizing BALB/c mice with a natural variant of human IL-13 known as R130Q. The humanized version H2L6 was generated by grafting CDRs of mouse antibody onto selected human heavy chain and light chain frameworks and finally site-directed mutagenesis of two methionine in the CDRs of heavy chain with binding affinity optimization resulted in the generated of M1295.

-20°C,2°C to 8°C

12352203