Anti-M-CSF [Celine], Rabbit IgG, lambda

Absolute Antibody

Anti-M-CSF [Celine], Rabbit IgG, lambda

9

The original version of this antibody (human IgG1) was tested for its specificity for human M-CSF and cross-reactivity for cynomolgus M-CSF using ELISA. This antibody binds M-CSF expressed on cells, as shown in a FACS assay that exhibited an EC50 value of 9.7 nM and 13 nM against M-CSF-expressing transfected CHO cells and MDA-MB 231 cells, respectively. This antibody successfully inhibited human and cynomolgus M-CSF binding to recombinant human M-CSF receptor with an IC50 of 4.7 pM and 6.9 pM, respectively. This antibody successfully inhibited the proliferation of M-NFS-60 cells induced by recombinant and native human and cynomolgus M-CSF with an IC50 of 2.7 pM and 23.8 pM for recombinant and native human M-CSF, respectively, and 3.0 pM and 72.4 pM for recombinant and native cynomolgus M-CSF, respectively (US10081675B2).

Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Celine

CSF1

colony stimulating factor 1

CSF-1, MCSF, PG-M-CSF, macrophage colony-stimulating factor 1, CSF1-hERV-LTR71B fusion protein, colony stimulating factor 1 (macrophage), lanimostim, macrophage colony stimulating factor 1, proteoglycan macrophage colony-stimulating factor

Rabbit

IgG

Macrophage colony-stimulating factor 1

-20°C,2°C to 8°C

12352203