Anti-M-CSF [RX1], Human IgG1, Fc Silent(tm), kappa

Absolute Antibody

Anti-M-CSF [RX1], Human IgG1, Fc Silent(tm), kappa

9

The antibody is specific for M-CSF. The antibody binds to a linear epitope of M-CSF (amino acids 98-105).

The binding properties of the original format of the antibody were analyzed using SPR analyses (Kd = 0.16 nM). The antibody could neutralize human M-CSF activity, as measured by a proliferation assay with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able to neutralize human M-CSF activity, but with less potency. The humanized variant of the antibody was constructed (EP1913028B1).

Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

RX1

CSF1

colony stimulating factor 1

colony stimulating factor 1 (macrophage); CSF-1; lanimostim; macrophage colony stimulating factor 1; macrophage colony-stimulating factor 1; MCSF

Human

IgG1

Macrophage colony-stimulating factor 1

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

-20°C,2°C to 8°C

12352203