anti-MBNL1 antibody

Arigo Biolaboratories

anti-MBNL1 antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

MBNL1

muscleblind like splicing regulator 1

EXP, MBNL, muscleblind-like protein 1, muscleblind-like, triplet-expansion RNA-binding protein

Rabbit

IgG

This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015]

-20°C

12352203