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ProductsBack/anti-MDA5 (mouse), pAb (AL180)
Western blot analysis anti-MDA5 (mouse), pAb (AL180) (Prod. No. AG-25B-0001) detecting the cleavage of endogenous mouse MDA5 as an indicator of apoptosis. Method: Cleavage of endogenous Helicard in murine A20 B lymphomas undergoing Fas-mediated apo
Western blot analysis anti-MDA5 (mouse), pAb (AL180) (Prod. No. AG-25B-0001) detecting the cleavage of endogenous mouse MDA5 as an indicator of apoptosis. Method: Cleavage of endogenous Helicard in murine A20 B lymphomas undergoing Fas-mediated apo
Western blot analysis anti-MDA5 (mouse), pAb (AL180) (Prod. No. AG-25B-0001) detecting the cleavage of endogenous mouse MDA5 as an indicator of apoptosis. Method: Cleavage of endogenous Helicard in murine A20 B lymphomas undergoing Fas-mediated apo

anti-MDA5 (mouse), pAb (AL180)

Research Use Only
AG-25B-0001V
AdipoGen Life Sciences
ApplicationsWestern Blot, ImmunoHistoChemistry
DownloadMSDS
Product group Antibodies
ReactivityMouse
TargetIfih1
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-MDA5 (mouse), pAb (AL180)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes mouse MDA5.
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Estimated Purity
    >95%
  • Gene ID71586
  • Target name
    Ifih1
  • Target description
    interferon induced with helicase C domain 1
  • Target synonyms
    9130009C22Rik; Heli; Helicard; helicase with 2 CARD domains; Hlcd; interferon induced with helicase C domain protein 1; interferon-induced helicase C domain-containing protein 1; MDA; MDA-; MDA5; melanoma differentiation-associated protein 5; RIG-I-like receptor 2; RLR-2
  • Host
    Rabbit
  • Scientific Description
    Polyclonal Antibody. Recognizes mouse MDA5. Source: Rabbit. Applications: IHC, WB. Liquid. In PBS containing 0.02% sodium azide. RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. MDA5, upon interaction with intracellular dsRNA (produced during viral replication), triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappaB, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). MDA5 is widely expressed at low levels. The expression is detected at higher levels in placenta, pancreas and spleen and barely in brain, testis and lung. Genetic variation in MDA5 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. - RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. MDA5, upon interaction with intracellular dsRNA (produced during viral replication), triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappaB, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). MDA5 is widely expressed at low levels. The expression is detected at higher levels in placenta, pancreas and spleen and barely in brain, testis and lung. Genetic variation in MDA5 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203