Western blot: Lanes 1 and 2 are WT MEK 1 and Lanes 3 and 4 are mutant MEK 1 (T292A) stained with ARG52334 anti-MEK1 phospho (Thr292) antibody showing the ~45k MEK-1 protein phosphorylated at Thr292 signal could be detected.
Western blot: Lanes 1 and 2 are WT MEK 1 and Lanes 3 and 4 are mutant MEK 1 (T292A) stained with ARG52334 anti-MEK1 phospho (Thr292) antibody showing the ~45k MEK-1 protein phosphorylated at Thr292 signal could be detected.
anti-MEK1 phospho (Thr292) antibody
ARG52334
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Canine, Human, Mouse, Primate, Rat
TargetMAP2K1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-MEK1 phospho (Thr292) antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5604
- Target nameMAP2K1
- Target descriptionmitogen-activated protein kinase kinase 1
- Target synonymsCFC3; dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; MEK1; MEL; MKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionMEK 1 (MAP kinase kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). This pathway also plays a key role in synaptic plasticity in the brain (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992). Conversely, there also appears to be a feedback phosphorylation of MEK 1 by MAP kinase. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386 (Mansour et al., 1994).
- ReactivityBovine, Canine, Human, Mouse, Primate, Rat
- Storage Instruction-20°C
- UNSPSC12352203