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Anti-Mesothelin [MN-1]

Research Use Only
AB03251-2.3
Absolute Antibody
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Other Application
Product group Antibodies
ReactivityHuman
TargetMSLN
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Overview

  • Supplier
    Absolute Antibody
  • Product Name
    Anti-Mesothelin [MN-1]
  • Delivery Days Customer
    7
  • Antibody Specificity
    This antibody can recognize and bind human mesothelin. This antibody binds a different antibody on the human mesothelin than another antibody called MB. Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)-linked cell surface protein highly expressed in
  • Application Supplier Note
    The binding characterization of this antibody was done using ELISA and SPR. The binding affinity of the original IgG2a antibody for mesothelin-Fc protein was determined by BIACore and reported to be Kd = 1.0 nM. This antibody can recognize membrane bound mesothelin on the surface of mesothelin positive H226, A1847, Hela and Panc3.014 cells (mesothelin-positive) in a flow cytometry. This antibody can also bind denatured human mesothelin in a western blot assay. This antibody was also used in the immunohistochemical staining of cancerous tissue like ovarian adenocarcinoma and normal tissues like peritoneal mesothelium on uterus, pleural mesothelium on lung and fallopian tube luminal fluid (PMID: 16115924). This antibody was also used in an immunohistochemical analysis of 1562 tumors for mesothelin expression. It was reported that mesothelin was highly expressed in ovarian serous carcinoma, pancreatic adenocarcinoma and malignant pleural mesothelioma (PMID: 28460459). This antibody was also used in the immunoprecipitation of mesothelin from cell lysates (PMID: 23694968).
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Other Application
  • Applications Supplier
    ELISA; SPR; FC; WB; IHC; IP
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    MN-1
  • Gene ID10232
  • Target name
    MSLN
  • Target description
    mesothelin
  • Target synonyms
    CAK1 antigen; megakaryocyte potentiating factor; mesothelin; MPF; pre-pro-megakaryocyte-potentiating factor; SMRP; soluble MPF mesothelin related protein
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDQ13421
  • Protein Name
    Mesothelin
  • Reactivity
    Human
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    The original antibody was generated in mesothelin-deficient mice by immunization with plasmid cDNA corresponding to the mesothelin extracellular domain followed by a single boost with a recombinant human mesothelin-rabbit IgG Fc fusion protein.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203